Title: "Fluctuation-dissipation relations and the computation of response functions out of equilibrium" Abstract: A unified derivation of the off-equilibrium fluctuation-dissipation relations (FDR) is given for Ising and continous spins to arbitrary order in the external perturbation, within the framework of Markovian stochastic dynamics. Similarities and differences with other forms of FDR in the literature are analysed and discussed. Knowledge of the FDR allows to develop "zero field" algorithms for the efficient numerical computation of the response functions. The method based on our form of the FDR is illustrated in the phase-ordering process of the Ising ferromagnet quenched to below the critical point and in the Edwards-Anderson spin glass, where a second ordere FDR is needed. As an additional application, the effective temperature is extracted at nonlinear order, in the context of coarsening systems, and is shown to be consistent with the one obtained from the linear FDR.